Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.
Ephrin B1 is expressed on human luteinizing granulosa cells in corpora lutea of the early luteal phase: the possible involvement of the B class Eph-ephrin system during corpus luteum formation.
Presenilin-dependent intramembrane cleavage of ephrin-B1.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A physical wiring diagram for the human immune system.
Multimodal cell maps as a foundation for structural and functional genomics.
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3.
Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
EPH receptors autophosphorylate
EPH:EFN tetramers oligomerise
p190RhoGEF exchanges GTP for GDP on RHOA, activating it
N-WASP binds ARP2/3 and G-actin
EPH:EFN dimers tetramerise
Recruitment of p190RhoGEF to p-FAK
CDC42 and PIP2 bind WASL, activating it
SFKs phosphorylate VAV2,3
KALRN exchanges GTP for GDP on RAC1, activating it
EPHB phosphorylates TIAM1
VAV exchanges GTP for GDP on RAC1, activating it
bPIX exchanges GTP for GDP on RAC, activating it
Clathrin internalises EPH:EFN complexes
Ras:GTP binds p120-RasGAP
p-EPHB phosphorylates SDC2
p-TIAM1 exchanges GTP for GDP on RAC1, activating it
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex.
Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.
Author Correction: A physical wiring diagram for the human immune system.
EFNB1 evidence replay results
EFNB1 source and evidence guide