Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.
Human ERG-2 protein is a phosphorylated DNA-binding protein--a distinct member of the ets family.
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ERG-2 is a nuclear phosphoprotein that binds purine-rich DNA sequences with consensus (C/G)(C/a)GG-AA(G/a)T.
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ERG-2 is phosphorylated by protein kinase C activation.
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ERG-2 expression is high in early myeloid cells, suggesting role in early hematopoietic differentiation.
Molecular composition of IMP1 ribonucleoprotein granules.
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.
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ERG binds to the VE-cadherin (CDH5) promoter and enhances its activity in transactivation assays.
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ERG inhibition results in decreased VE-cadherin expression, cell detachment, and increased endothelial apoptosis.
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ERG is required for endothelial tube formation and angiogenesis in vivo.
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.
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ERG is a positive regulator of CLDN5 expression in endothelial cells.
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ERG knockdown increases endothelial permeability.
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ERG is a positive regulator of EC-restricted genes including VE-cadherin, endoglin, and von Willebrand factor.
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ERG is a negative regulator of IL-8 and ICAM-1.
A transcriptional repressor co-regulatory network governing androgen response in prostate cancers.
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ERG interacts with AR, HDACs, and EZH2 in a transcriptional repressor network in prostate cancer.
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ERG, EZH2, and HDACs cooperate to repress cytoskeletal genes including Vinculin.
The mutational landscape of lethal castration-resistant prostate cancer.
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.
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ERG binds the ETS binding site (EBS) consensus 5'-GGA(A/T)-3' through its conserved ETS domain.
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ERG/DNA binding can be inhibited by heterocyclic diamidines targeting the DNA minor groove.
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ERG regulates the osteopontin promoter through direct EBS binding.
ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer.
ETS transcription factor ERG cooperates with histone demethylase KDM4A.
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ERG directly binds KDM4A histone demethylase.
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ERG and KDM4A cooperate to upregulate YAP1 transcription.
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ERG expression reduces H3K9me3 at the YAP1 promoter.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Genetic association analysis of 77,539 genomes reveals rare disease etiologies.