Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.

Towards a proteome-scale map of the human protein-protein interaction network.

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.

Interaction between glycogenin and glycogen synthase.

Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts.

Defining the membrane proteome of NK cells.

Phosphate incorporation during glycogen synthesis and Lafora disease.

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β.

A proteome-scale map of the human interactome network.

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.

GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

Autoglucosylation of GYG1 complexed with GYS1-b

GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a

Autoglucosylation of GYG1 complexed with GYS1-a

Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b

Glycogen synthesis

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex

NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1

EPM2A dimer dephosphorylates phosphoglycogen-GYG1

PPP1R3C binds to glycogen:GYG1:GYS1

GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1

Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)

Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)

Defective GYG1 is not autoglucosyolated

Defective GYS1 does not transfer glucose to growing glycogen chains