Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural basis for FGF receptor dimerization and activation.
A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2.
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.
The structure and function of vertebrate fibroblast growth factor receptor 1.
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity.
90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
Cellular signaling by fibroblast growth factor receptors.
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome.
Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
Fibroblast growth factor receptors from liver vary in three structural domains.
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.
Complete sequence of a human receptor for acidic and basic fibroblast growth factors.
Diverse forms of a receptor for acidic and basic fibroblast growth factors.
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1.
Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity.
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
MiR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Physical and functional interactome atlas of human receptor tyrosine kinases.
A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome.
Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants.
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
Receptor specificity of the fibroblast growth factor family.
Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Activated FGFR1 mutants and fusions bind PLCG1
Activated FGFR1 mutants and fusions phosphorylate PLCG1
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
FGFR1c binds to Klotho-bound FGF23
Autocatalytic phosphorylation of FGFR1b
Autocatalytic phosphorylation of FGFR1c
Autocatalytic phosphorylation of Klotho-bound FGFR1c
Ligand-independent dimerization of overexpressed FGFR1b
Ligand-independent phosphorylation of overexpressed FGFR1
FGFR1c P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
Dimerization of FGFR1 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
L1-FGFR cis-heterodimerization
Activated FGFR1 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR1
Activated FGFR1 binds PLCG1
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Ligand-independent dimerization of overexpressed FGFR1c
Ligand-independent phosphorylation of overexpressed FGFR1c
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated FGFR1 binds FRS2
Activated FGFR1 binds FRS3
Activated FGFR1 binds SHC1
Activated FGFR1 phosphorylates FRS2
Activated FGFR1 phosphorylates FRS3
Activated FGFR1 phosphorylates SHC1
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS phosphorylates PPTN11
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR1 mutants bind FRS2
Activated FGFR1 mutants phosphorylate FRS2
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1 binds FLRT1,2,3
RAS GEFs promote RAS nucleotide exchange
Plasma membrane FGFR1 fusions dimerize
Plasma membrane FGFR1 fusions autophosphorylate
UniProtKB entry P11362 (FGFR1_HUMAN)
Falcon deep research report on human FGFR1
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
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FGF19 and FGF21 signal through betaKlotho-bound FGFR1-3; FGF21 acts on adipocytes expressing FGFR1.
"Both FGF19 and FGF21 can signal through FGFR1-3 bound by betaKlotho and increase glucose uptake in adipocytes expressing FGFR1."