Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
The CacyBP/SIP protein is sumoylated in neuroblastoma NB2a cells.
Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.
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Loss of CG3226 causes dilated cardiomyopathy in adult flies, rescued by genomic and heart-specific CG3226 expression.
"Heart specific expression of CG3226 rescued heart function in Df(1)Exel6240"
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The fly SIP ortholog has not been tested biochemically in the Sina complex or the Armadillo pathway.
"The Drosophila gene orthologous to SIP has not been characterized in the Sina complex nor in the Drosophila Armadillo pathway"
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
Structural and functional diversification in the teleost S100 family of calcium-binding proteins.
Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family.
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S100 proteins are found in vertebrates and a few tunicates, not in cephalochordates, hemichordates or echinoderms searched.
"All S100 hits were within vertebrates, with the exception of four hits from the tunicate Oikopleura dioica"
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
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S100 proteins are described as a vertebrate-specific family.
"The calcium-binding, vertebrate-specific S100 protein family"
Taxonomic distribution of S100 (PF01023) proteins, InterPro API
UniProtKB Q9W3Y3 entry for CG3226 (DROME)