Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:19826053

Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.

In vitro fatty acid elongation assays show ELOVL7 preferentially elongates saturated very-long-chain fatty acids; ELOVL7 is androgen/SREBP1-regulated and its knockdown attenuates prostate cancer cell growth.

PMID:20937905

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

In vitro determination of the substrate specificities of all seven human ELOVLs; establishes ELOVL7 substrate range and ER-membrane localization.

PMID:21959040

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7.

Purified, proteoliposome-reconstituted ELOVL7 has high elongase activity toward C18 acyl-CoAs (Km(C18:3(n-3)-CoA)=2.6 uM, Km(malonyl-CoA)=11.7 uM); His-150/His-151 are required for activity.

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:34117479

The structural basis of fatty acid elongation by the ELOVL elongases.

Crystal structure of human ELOVL7 (PDB 6Y7F) with a covalently bound 3-keto acyl-CoA reveals a seven-TM inverted barrel; the first, rate-limiting condensation step proceeds via a ping-pong acyl-imidazole intermediate on His-150 of the HxxHH motif. ELOVL7 forms a homodimer.

PMID:38422897

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation.

Structural/biochemical study of the VLCFA elongation machinery (ELOVL/KAR/HACD/TECR); source of the curated ELOVL7-TECR interaction.

Reactome:R-HSA-548814

ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

Reactome:R-HSA-548815

ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

Reactome:R-HSA-75876

Synthesis of very long-chain fatty acyl-CoAs