Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4.
ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.
Search for cellular partners of human papillomavirus type 16 E2 protein.
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
Selective inhibition of BET bromodomains.
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation.
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular functions.
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells.
Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.
A Y2H-seq approach defines the human protein methyltransferase interactome.
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA.
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
Architecture of the human interactome defines protein communities and disease networks.
Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.
BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Identification and functional characterization of transcriptional activators in human cells.
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
BRD4 binding to CD274 gene chromatin
Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.
The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains.
BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.