Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria.
ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System.
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
A central chaperone-like role for 14-3-3 proteins in human cells.
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
Alpha-protein kinase 1 signaling pathway
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
ALPK1:ADP-heptose binds TIFA
ALPK1 phosphorylates TIFA
Ubiquitination of IKBKG by TRAF6
Corrigendum: ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants.
ALPK1 mutants causing ROSAH syndrome or Spiradenoma are activated by human nucleotide sugars.
The β-d-manno-heptoses are immune agonists across kingdoms.
UniProtKB Q96QP1 ALPK1 human record