Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.
Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.
The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.
Next-generation sequencing to generate interactome datasets.
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation.
Problems identified by secondary review of accepted manuscripts.
Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
USP25 regulates Wnt signaling by controlling the stability of tankyrases.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
A proteome-scale map of the SARS-CoV-2-human contactome.
USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Heterozygous variants in USP25 cause genetic generalized epilepsy.
Multimodal cell maps as a foundation for structural and functional genomics.
Ub-specific processing proteases (deubiquitination)
Ub-specific processing proteases