Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25.

Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues.

Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis.

Oxidation of cholesterol to 22beta-hydroxycholesterol

Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

CYP11A1 cleaves 20a,22b-DHCHOL

FDXR transfers electrons to FDX1,2 (FDX1L)

Electron transport from NADPH to Ferredoxin

NADPH transfers electrons to FDXR

Defective CYP11A1 does not cleave 20a,22b-DHCHOL

Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.

FDXR variants cause adrenal insufficiency and atypical sexual development.

Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system.

Dissecting the Biological Functions of Various Isoforms of Ferredoxin Reductase for Cell Survival and DNA Damage Response.