Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProtKB P17405 (ASM_HUMAN) record for human SMPD1 / acid sphingomyelinase
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.
Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multi-approach study.
The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor.
Molecular basis of acid sphingomyelinase deficiency in a patient with Niemann-Pick disease type A.
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs.
Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models.
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.
Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.
Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease.
Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity.
Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.
Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.
Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis.
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.
SMPD1 converts sphingomyelin to ceramide
Glycosphingolipid catabolism