GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/purM/purM-uniprot.txt

UniProtKB entry Q88MA9 for Pseudomonas putida KT2440 purM

UniProt identifies Q88MA9 as Phosphoribosylformylglycinamidine cyclo-ligase.

"RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase"

file:projects/TREEGRAFTER/rereview-2026-09-20/metabolic-comparators.json

Live QuickGO ontology and experimental comparator snapshot for metabolic-scope review

Exact GO:0046084 experimental annotations include Candida ADE5:7, yeast ADE8 and fission-yeast ade7, establishing usage for upstream de novo purine enzymes.

file:PSEPK/purM/purM-comparator-ADE5-7.json

Live UniProt A0A1D8PE67 comparator record for Candida ADE5:7

The adenine-biosynthesis comparator contains the same AIR-synthetase activity as standalone bacterial PurM.

"In the C-terminal section; belongs to the AIR synthase family"

PMID:17600079

Role of the Vps34p-interacting protein Ade5,7p in hyphal growth and virulence of Candida albicans.

Candida ADE5,7 deletion causes adenine deficiency; the protein is a bifunctional de novo purine enzyme and serves as a term-usage comparator.

"resulting mutants were adenine deficient"

file:projects/TREEGRAFTER/rereview-2026-09-20/cache-reports/openscientist-commissioned-review-brief-revi-1a1f035d.md

Cached OpenScientist de novo IMP biosynthesis review

The report distinguishes bacterial PurM from the AIRS domain of fused GART and assigns ATP-dependent ring cyclization.

"| 5 | AIR formation | PurM | GART (AIRS domain) | ATP-dependent cyclo-ligase; conserved dimer (PMID: 26515187) |"