Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.
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ATN1 represses a transfected reporter; the original Methods establish human constructs.
"in a cell transfection-based assay, atrophin-1 represses transcription."
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.
Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.
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ATN1 and RERE show FAT1 association; their construct species are distinguished in the source notes.
"In coimmunoprecipitation studies, Fat1 interacted with both Atr1
and Atr2;"
Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.
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ATN1 is explicitly among the reported GIGYF2-associated proteins.
"GIGYF2 interacts not only with mRNA surveillance factors, but
also with vesicular transport proteins and Atrophin-1."
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A High-Density Map for Navigating the Human Polycomb Complexome.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain.
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
Functional architecture of atrophins.
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Atrophin-1 and short Atrophin-2 display transcriptional activation in the reported assays; the externally read target experiment uses mouse ATN1.
"Atrophin-1
and the short form of Atrophin-2, on the other hand, can act as potent and
evolutionarily conserved transcriptional activators."
UniProt entry Q96QZ7 (MAGI1_HUMAN), Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1