Gene Ontology annotation by the MGI curatorial staff, curated orthology

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

The protooncogene TCL1 is an Akt kinase coactivator.

Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

The role of Asp-462 in regulating Akt activity.

Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.

Protein kinase B alpha/Akt1 regulates placental development and fetal growth.

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.

Akt signaling regulates side population cell phenotype via Bcrp1 translocation.

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.

The costimulation-regulated duration of PKB activation controls T cell longevity.

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.

IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells.

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.

Role for Akt3/protein kinase Bgamma in attainment of normal brain size.

Phosphorylation of grb10 regulates its interaction with 14-3-3.

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function.

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death.

Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2.

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.

Akt and CHIP coregulate tau degradation through coordinated interactions.

Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop.

Akt activation prevents Apop-1-induced death of cells.

Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.

Akt promotes BMP2-mediated osteoblast differentiation and bone development.

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes.

Evidence for the involvement of FAM110C protein in cell spreading and migration.

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth.

AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.

Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions.

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination.

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.

Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation.

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.

BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.

Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency.

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.

Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.

Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.

The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells.

MicroRNA-23a promotes myelination in the central nervous system.

KCTD20, a relative of BTBD10, is a positive regulator of Akt.

MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells.

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.

PTEN degradation after ischemic stroke: a double-edged sword.

Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts.

Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.

Phosphoinositide 3-kinase p85beta regulates invadopodium formation.

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.

Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.

PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression.

Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth.

Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome.

Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.

Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice.

The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.

Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis.

Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation.

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.

Akt Phosphorylates As160 (Tbc1d4)

Phosphorylation of PDE3B by AKT-1

Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)

p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)

Akt1 binds phosphoinositol-3,4,5-trisphosphate

Activation of Akt1 by shear stress in osteocytes

BioReason deep research report on Akt1

Falcon deep research summary for mouse Akt1

AIGR curator notes for Akt1