Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Ribonuclease activity and RNA binding of recombinant human Dicer.
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP.
Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.
The role of PACT in the RNA silencing pathway.
Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.
MicroRNA silencing through RISC recruitment of eIF6.
RNA helicase A interacts with RISC in human cells and functions in RISC loading.
Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer.
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
In vitro reconstitution of the human RISC-loading complex.
HCV core protein interacts with Dicer to antagonize RNA silencing.
Autoinhibition of human dicer by its internal helicase domain.
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling.
Structural insights into RNA processing by the human RISC-loading complex.
Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing.
Dicer recognizes the 5' end of RNA for efficient and accurate processing.
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes.
WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation.
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells.
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain.
Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.
NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G(1)/S phase transition.
Exploring the Human-Nipah Virus Protein-Protein Interactome.
TWEAK Negatively Regulates Human Dicer.
The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Dicer cleaves pre-miRNA to yield duplex miRNA
MicroRNA (miRNA) biogenesis
Duplex miRNA is loaded into Argonaute
Removal of siRNA passenger strand
Duplex siRNA is loaded into Argonaute
Removal of miRNA passenger strand
Dicer cleaves double-stranded RNA to yield double-stranded siRNA
Small interfering RNA (siRNA) biogenesis
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
MITF-M dependent DICER1 gene expression
Single processing center models for human Dicer and bacterial RNase III.
A novel splice variant of the human dicer gene is expressed in neuroblastoma cells.
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis.
Author Correction: An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.
Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics.
Characterization of a naturally occurring truncated Dicer.
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination.
Reduction of Dicer impairs Schwann cell differentiation and myelination.
Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid.
Dicer in Schwann cells is required for myelination and axonal integrity.