Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Homology of placental protein 11 and pea seed albumin 2 with vitronectin.
The tumor marker human placental protein 11 is an endoribonuclease.
Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker.
The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging.
Immunohistochemical detection of pregnancy-specific protein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in ovarian adenocarcinomas.
Deep research on ENDOU function
OpenAI deep research on ENDOU function (2026)
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ENDOU cleaves CHOP mRNA uORF to promote translation during ER stress
"ENDOU cuts the CHOP uORF at a specific site (between a G and a U nucleotide in the uORF sequence), generating a truncated mRNA segment. This cleavage allows ribosomes to bypass the uORF and re-initiate at the main coding sequence, markedly increasing CHOP protein synthesis"
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EndoU regulates B cell activation-induced cell death by downregulating c-Myc
"EndoU is upregulated in B cells undergoing AICD. When EndoU was knocked out or disrupted, these B cells failed to undergo cell death - EndoU loss prevented AICD, allowing potentially autoreactive B cells to survive. EndoU activity appears to help downregulate c-Myc post-transcriptionally"
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Calcium ions allosterically activate ENDOU via conformational change
"calcium binding triggers an allosteric conformational change that activates the enzyme. The Ca2+ ion binds at a site remote from the catalytic triad, bridging parts of the N-terminal extension and the core; this interaction induces structural rearrangements that align the catalytic residues properly for RNA cleavage"
Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition
EndoU is a novel regulator of AICD during peripheral B cell selection
Molecular basis for the calcium-dependent activation of the ribonuclease EndoU
Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction.
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ENDOU protein is upregulated in cytotrophoblasts from placentas complicated with preeclampsia and fetal growth restriction (PE-FGR), based on LC-MS/MS differential proteomics
"ENDOU (endonuclease, poly(U) specific), which has high homology with the coronavirus endoribonuclease nonstructural protein 15 (Nsp15), showed a significantly increased expression in cytotrophoblasts from the placenta with fetal growth restriction related to preeclampsia compared with those in normal control placenta"
Falcon deep research on ENDOU function (2026)
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Catalytic residues E243, H244, E249, H259, K302 identified by site-directed mutagenesis as required for endoribonuclease activity
"identified residues required for cleavage activity: **E243, H244, E249, H259, and K302** (human numbering as reported). Mutants substantially lost processing activity while retaining RNA-binding in mobility-shift assays"
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ENDOU is upregulated in PE-FGR cytotrophoblasts (placental pathology signal)
"Proteomics on isolated placental cytotrophoblasts found ENDOU to be **upregulated** in placentas complicated by **preeclampsia with fetal growth restriction (PE-FGR)** relative to controls"
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Human ENDOU expression in Drosophila fat body rescues arlr lipid phenotype, supporting conserved mRNA-level regulation of lipid metabolism
"transgenic full-length human ENDOU** expressed in fly fat body **rescued** arlr mutant phenotypes (lipid droplet size and total triacylglycerol levels) and reduced mRNA levels of candidate lipolysis genes"
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ENDOU has a context-dependent tumor association - historically an oncofetal tumor marker (PP11) but downregulated with a tumor-suppressive role in HNSCC and cervical squamous cell carcinoma
"In **head and neck squamous cell carcinoma (HNSCC)**, ENDOU was identified as an **independent survival marker** candidate; ENDOU overexpression reduced proliferation and migration in cell lines"
Integrated Analysis Reveals ENDOU as a Biomarker in Head and Neck Squamous Cell Carcinoma Progression.
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ENDOU is downregulated in HNSCC and acts as a tumor suppressor - overexpression inhibits proliferation and migration of FaDu and Cal-27 cells
"In-vitro ENDOU overexpression inhibited FaDu and Cal-27 cells proliferation and migration, indicating its tumor-suppressing role in HNSCC progression"
Integrative meta-analysis of gene expression profiles identifies FEN1 and ENDOU as potential diagnostic biomarkers for cervical squamous cell carcinoma.