Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Maps Hydrolase keyword to GO:0016787
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Maps Glycosidase keyword to GO:0016798
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Maps Cellulose degradation keyword to GO:0030245
Combined Automated Annotation using Multiple IEA Methods
UniProt entry for Endoglucanase D from A. thermocellus
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EC 3.2.1.4 classification confirms cellulase activity
"RecName: Full=Endoglucanase D; Short=EGD; EC=3.2.1.4"
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Dockerin domain enables cellulosome incorporation
"InterPro; IPR002105; Dockerin_1_rpt"
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Ca2+ cofactor required with EF-hand binding sites
"Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}"
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Signal peptide indicates secreted protein
"AltName: Full=Endo-1,4-beta-glucanase; Flags: Precursor"
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GH9 family member per CAZy database
"CAZy; GH9; Glycoside Hydrolase Family 9"
Nucleotide sequence of the cellulase gene celD encoding endoglucanase D of Clostridium thermocellum.
Organization of a Clostridium thermocellum gene cluster encoding the cellulosomal scaffolding protein CipA and a protein possibly involved in attachment of the cellulosome to the cell surface.
Deep research summary for CelD
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CelD is a GH9 endoglucanase that integrates into the cellulosome via dockerin-cohesin interaction
"CelD (celD; A3DDN1) from C. thermocellum ATCC 27405 is a secreted, cellulosomal GH9 endoglucanase (EC 3.2.1.4) that integrates via dockerin-cohesin into the CipA scaffold"
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Scaffoldin-mediated targeting enhances CelD binding and activity on crystalline cellulose
"Scaffoldin-mediated targeting strongly enhances CelD's binding and activity on crystalline cellulose"