Cul2 (Cullin-2) review notes

Accession: Q9V9R2. Planned FlyBase gene-group module (not yet committed to modules/ on main): dmel_vcb_ubiquitin_ligase (Cul2-Roc1a catalytic core).

Literature journal

• VCB-Cul2 PMID:11006129; Roc1a binds Cul1-4 PMID:18698375.
• JAK/STAT with Socs36E: PMID:26277564
• Ovarian niche Dpp PMID:26206612; testis germline enclosure PMID:25459658; NMJ and female germline PMID:21869472; CrPV-1A PMID:30308158.

Decisions

• Core MF GO:0160072 scaffold, contributes_to GO:0061630; GO:0031462. Same pattern as Cul1.
• SCF ubiquitin ligase complex and SCF-dependent catabolism IBA rows (node PTN000231993, all Cul1 donors): REMOVE as over-propagation to the Cul2 paralog.
• General terms MODIFY: GO:0006511/GO:0030163 -> GO:0043161; GO:0031461 -> GO:0031462.
• GO:0016567 ACCEPT (fly evidence shows ubiquitination without chain type; as precise as warranted), same as Vhl.

Deep research (falcon, added after the initial review)

The falcon deep-research run finished after the initial commit and is now in Cul2-deep-research-falcon.md. Its synthesis is consistent with the annotation decisions above; no review actions were changed.

Revision after PR #4471 review

• GO:0016032 viral process is now KEEP_AS_NON_CORE rather than MARK_AS_OVER_ANNOTATED: GO uses this term for host products that take part in a viral life cycle (CrPV-1A co-opts the host Cul2-EloBC ligase), matching the precedent in genes/ECOLI/DnaJ. This replaces the earlier viral-process decision above.
• The positive-regulation-of-catabolism reason now names GO:0043161 (not the SCF term) as the direct process; GO:0048471 no longer carries an off-topic quote; GO:0043161 added to core function.