Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
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D7r4 identified in female Anopheles gambiae saliva by mass spectrometry
"A proteomic and immunoproteomic analysis of anopheles and Aedes saliva allowed for the identification of some antigens that were recognized by most of the exposed individuals"
The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae
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Crystal structures of D7r4 with bound biogenic amines solved at high resolution
"The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae"
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D7r4 has a fold with eight alpha-helices and binding pocket for amines
"The D7 fold consists of an arrangement of eight alpha-helices stabilized by"
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Crystal structure reveals ligand binding pocket
"and structure of the ligand binding pocket. The pocket itself is lined by"
Function and evolution of a mosquito salivary protein family
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D7 short proteins bind serotonin, histamine and norepinephrine with high affinity
"four of these five short D7 proteins and the D7 long form bind serotonin with high affinity, as well as histamine and norepinephrine"
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Scavenging host amines antagonizes vasoconstriction and platelet aggregation
"Scavenging of host amines would antagonize their vasoconstrictor, platelet-aggregating, and pain-inducing properties"
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D7 family is distantly related to odorant-binding proteins but has distinct function
"The D7 salivary family of proteins is abundantly expressed in blood-feeding Diptera and is distantly related to the odorant-binding protein superfamily"
A cluster of four D7-related genes is expressed in the salivary glands of the African malaria vector Anopheles gambiae
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D7r genes are expressed in adult female salivary glands
"Four genes expressed in the Anopheles gambiae adult female salivary glands and similar in sequence to the Aedes aegypti D7 gene were identified"
Novel cDNAs encoding salivary proteins from the malaria vector Anopheles gambiae
UniProt entry for D7R4_ANOGA
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D7r4 modulates blood feeding by binding host mediators
"Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response"
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Binds serotonin, noradrenaline, histamine and tryptamine
"Binds serotonin, noradrenaline, histamine and tryptamine (PubMed:16301315, PubMed:17928288)"
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Inhibits smooth muscle contraction induced by biogenic amines
"Inhibits histamine-, serotonin- and partially noradrenaline-induced smooth muscle contraction (PubMed:16301315)"
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Exhibits vasodilating activity
"Exhibits vasodilating activity (PubMed:16301315)"
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Expressed in female saliva and salivary gland
"-!- TISSUE SPECIFICITY: Female saliva (at protein level) (PubMed:17913537). Female salivary gland (PubMed:12062411). Not detected in female carcass without salivary glands (PubMed:12062411). Not detected in male tissues"
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Protein is secreted
"-!- SUBCELLULAR LOCATION: Secreted"
Deep research review of D7 protein family function and evolution
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D7 proteins function as kratagonists that scavenge host signaling molecules
"D7 proteins are among the most abundant mosquito salivary proteins and function as kratagonists—high-affinity scavengers of host small-molecule inflammatory and hemostatic mediators"
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Short-form D7s bind biogenic amines
"short-form D7s (including D7r1) predominantly bind biogenic amines (serotonin/5-HT, histamine, epinephrine/norepinephrine)"
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D7 proteins are secreted in saliva during feeding
"D7r1 is produced in adult female salivary glands and secreted in saliva at the skin interface during probing/feeding"
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Crystal structure of D7r4 reveals binding pocket for biogenic amines
"The crystal structure of An. gambiae D7r4 revealed a modified OBP-like fold (eight alpha-helices, three disulfide bonds) and a binding pocket adapted to amine ligands"