Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion.
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BolA family proteins localize to mitochondria
"We show that BOLA1 is a mitochondrial protein"
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BOLA3 implicated in Fe-S cluster biogenesis for OXPHOS complexes
"BOLA3 has recently been implicated in the biogenesis of [Fe-S] clusters for oxidative phosphorylation complexes and 2-oxo acid dehydrogenase enzymes in mitochondria"
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BOLA proteins interact with GLRX5 glutaredoxin
"A measured interaction of BOLA1 with the mitochondrial monothiol glutaredoxin GLRX5 provides hints for potential mechanisms behind BOLA1's effect on mitochondrial redox potential"
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins.
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BOLA3 is a mitochondrial ISC assembly factor
"we characterize the BOLA family proteins Bol1 and Bol3 as specific mitochondrial ISC assembly factors"
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BOLA3 facilitates [4Fe-4S] cluster insertion into LIAS and SDH
"facilitate [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoate synthase and succinate dehydrogenase"
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BOLA3 forms heterocomplex with GLRX5 bridged by [2Fe-2S] cluster
"Bol1 and Bol3 form dimeric complexes with both monothiol glutaredoxin Grx5 and Nfu1"
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Cys59 and His96 are cluster ligands in BOLA3
"residues Cys59 and His96 are conserved within the BOLA3 proteins"
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BOLA3 interacts with NFU1 for [4Fe-4S] assembly
"Bol1 and Bol3 form dimeric complexes with both monothiol glutaredoxin Grx5 and Nfu1"
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 2 Caused by CYS59TYR BOLA3 Mutation.
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C59Y mutation perturbs Fe-S cluster-binding region of BOLA3
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C59Y BOLA3-GLRX5 complex still binds [2Fe-2S] cluster
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Mutation forms aberrant apo BOLA3-GLRX5 complex
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Explains partial phenotype recovery in some MMDS2 patients
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Deep research report on BOLA3