BAT1 (YHR208W, P38891) notes

Batch: YeastPathways module branched_chain_amino_acid_biosynthesis (no paid deep research run).

Identity and activity

• Mitochondrial branched-chain amino acid aminotransferase, EC 2.6.1.42 [UniProt:P38891 "RecName: Full=Branched-chain-amino-acid aminotransferase, mitochondrial"].
• Matrix targeting: PMID:8798704.
• Activity: PMID:8798704; PMID:8702755.
• Double mutant auxotrophy: PMID:8798704.

Paralog subfunctionalization (WGD pair with BAT2)

• PMID:21267457
• PMID:21267457
• K. lactis single ortholog KlBat1 is bifunctional and presequence-bearing (ancestral state) PMID:21267457.

Secondary roles

• KMTB -> methionine transamination in methionine salvage (UniProt citing PMID:18625006, not cached) [UniProt:P38891 "from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage"]. Non-core.
• TORC1/cell-cycle links (UniProt, PMIDs 26659116, 37497662; not cached) likely metabolic/indirect; not annotated.

Curation observations

• 9 RCA is_active_in cytosol rows from YeastPathways: wrong for Bat1 (matrix) -> REMOVE.
• All 9 RCA MF rows use GO:0052656 (isoleucine transaminase) even where the YeastPathways reaction is the Leu (BRANCHED-CHAINAMINOTRANSFERLEU-RXN), Val, or methionine-salvage R15-RXN reaction: a conversion artefact. MF still true for the protein, so ACCEPT, flagged in suggested_questions.
• protein binding IPIs are all with the paralog Bat2 (HT AP-MS) -> REMOVE (uninformative).