Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation.
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KCTD10 interacts with PCNA, consistent with a nuclear, replication-associated role.
"KCTD10 can interact with PCNA."
Defining the human deubiquitinating enzyme interaction landscape.
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
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KCTD10 forms a pentameric BTB assembly typical of the KCTD family, the basis of its 5:5 assembly with CUL3.
"(KCTD10 and KCTD13), open pentamer (KCTD16) and closed pentamer (KCTD17)."
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.
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KCTD10 mediates K63-linked polyubiquitination of RHOB, targeting it for lysosomal degradation to preserve endothelial barrier function.
"RhoB is primarily K63 polyubiquitinated and subsequently degraded in lysosomes."
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
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KCTD10 directs proteasomal degradation of CEP97, enabling removal of the CEP97-CP110 complex from mother centrioles and primary cilium formation.
"Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation."
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Multimodal cell maps as a foundation for structural and functional genomics.
The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.
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KCTD10 (CRL3) destabilizes SLC7A11 by polyubiquitylation/proteasomal degradation, reducing cystine uptake and promoting ferroptosis; USP18 is the opposing deubiquitinase.
"KCTD10 destabilizes SLC7A11 by promoting its polyubiquitylation for subsequent proteasome degradation, leading to shortened protein half-life."