Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability.
Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells.
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain.
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78.
BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP.
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.
Roles of CHOP/GADD153 in endoplasmic reticulum stress.
Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.
Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function.
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Regulated release of ERdj3 from unfolded proteins by BiP.
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis.
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.
Defining the membrane proteome of NK cells.
The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin.
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
A human MAP kinase interactome.
Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Proteomic characterization of the human sperm nucleus.
The unfolded protein response: integrating stress signals through the stress sensor IRE1α.
Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.
GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
Dermokine-β impairs ERK signaling through direct binding to GRP78.
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
The endoplasmic reticulum stress response in aging and age-related diseases.
Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78.
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members.
Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
CotH3 mediates fungal invasion of host cells during mucormycosis.
SIL1, a causative cochaperone gene of Marinesco-Söjgren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP.
Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
Architecture of the human interactome defines protein communities and disease networks.
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.
Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Identification of Cellular Pathogenicity Markers for SIL1 Mutations Linked to Marinesco-Sjögren Syndrome.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A functional interaction between GRP78 and Zika virus E protein.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Quantitative fragmentomics allow affinity mapping of interactomes.
Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)
Dissociation of PERK:BiP Heterodimer
ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein
IRE1:BiP dissociates in response to unfolded protein