Gene Ontology annotation through association of InterPro records with GO terms

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:genes/SPHSM/tetX/tetX-uniprot.txt

UniProt flat file for tetX (Q06DK7)

UniProt describes TetX as an FAD-dependent monooxygenase that hydroxylates tetracycline at C11a.

"Reaction=tetracycline + NADPH + O2 + H(+) = 11a-hydroxytetracycline"

PMID:19187139

Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline.

The source strain carries functional tetX and transforms tetracycline.

"Sphingobacterium sp. PM2-P1-29 demonstrated the ability to transform tetracycline compared with killed controls."

PMID:26038239

Transformation of tetracycline by TetX and its subsequent degradation in a heterologous host.

TetX inactivates tetracyclines and affects tetracycline resistance in a heterologous host context.

"TetX is a flavin-dependent monooxygenase. It has been reported to inactivate all tested tetracyclines."

file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml

Curated ARO to GO mapping set for AMR gene families

The AMR mapping records TetX/tetracycline destructase as a GO molecular-function term gap.

"GO has no Tet(X)/tetracycline-destructase (flavin-dependent tetracycline monooxygenase) MF term."