Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
Characterization of interactions of Nck with Sos and dynamin.
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes.
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.
Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase.
Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling.
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation.
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.
unc-53 controls longitudinal migration in C. elegans.
Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance.
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
A novel proteomic screen for peptide-protein interactions.
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.
Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region.
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.
The elucidation of novel SH2 binding sites on PLD2.
Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling.
Sos-mediated activation of rac1 by p66shc.
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism.
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.
A protein domain-based interactome network for C. elegans early embryogenesis.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.
Charting the molecular network of the drug target Bcr-Abl.
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
Defining the human deubiquitinating enzyme interaction landscape.
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.
FCRL6 receptor: expression and associated proteins.
A human MAP kinase interactome.
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer.
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.
Activation of Src and transformation by an RPTPα splice mutant found in human tumours.
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
A directed protein interaction network for investigating intracellular signal transduction.
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Toward an understanding of the protein interaction network of the human liver.
Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1.
FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Inhibition of basal FGF receptor signaling by dimeric Grb2.
Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.
SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells.
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Threshold-controlled ubiquitination of the EGFR directs receptor fate.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
A proteome-scale map of the human interactome network.
A THEMIS:SHP1 complex promotes T-cell survival.
Phospho-tyrosine dependent protein-protein interaction network.
A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.
Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.
GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.
Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Architecture of the human interactome defines protein communities and disease networks.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs.
Maximizing binary interactome mapping with a minimal number of assays.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Regulation of microRNA expression by the adaptor protein GRB2.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
GRB2 is a BECN1 interacting protein that regulates autophagy.
Systematic identification of post-transcriptional regulatory modules.
Multimodal cell maps as a foundation for structural and functional genomics.
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
Functional interaction between c-Src and its mitotic target, Sam 68.
Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7.
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.
Differential interactions of human Sos1 and Sos2 with Grb2.
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.
5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting.
Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.
Subsets of epidermal growth factor receptors during activation and endocytosis.
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase.
An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain.
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
Bcr phosphorylated on tyrosine 177 binds Grb2.
Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2.
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
Regulation of Sos activity by intramolecular interactions.
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells.
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
BLNK: a central linker protein in B cell activation.
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins.
Dual function C-terminal domain of dynamin-1: modulation of self-assembly by interaction of the assembly site with SH3 domains.
PI3K-containing complexes phosphorylate PIP2 to PIP3
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
GRB2 is indirectly recruited to p-KIT through SHP2
Phosphorylation of GAB2 by SFKs
Activation of RAS by p-KIT bound SOS1
Synthesis of PIP3 from PIP2 by PI3K
PPTN11 dephosphorylates SPRY2
Indirect recruitment of PI3K to KIT via p(Y)-GAB2
Sustained activation of SRC kinase by SHP2
Dephosphorylation of Gab1 by SHP2
Dephosphorylation of PAG by SHP2
PI3K binds to EGF:EGFR:GRB2:GAB1
GAB1 phosphorylation by EGFR kinase
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
SHP2 dephosphorylates Tyr 992 on EGFR
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
GRB2:GAB1 binds to phosphorylated EGFR
GRB2:SOS1 complex binds to EGF:EGFR complex
Activation of SHP2 through the binding to phospho-Gab1
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
Assembly of EGFR complex in clathrin-coated vesicles
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
Ubiquitination of stimulated EGFR (CBL:GRB2)
Phosphorylation of CBL (EGFR:GRB2:CBL)
Localization of CBL:GRB2 to the membrane
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
p-BCR-pFGFR1 binds GRB2:GAB2
BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3
p-BCR-p-FGFR1 phosphorylates GAB2
BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
GRB2:SOS1 complex binds to the active receptor
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin
Interaction of Tie2 and Grb2
Indirect recruitment of GAB2 to p-KIT
Recruitment of CBL to KIT
GRB2:SOS interacts with p-KIT
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
Interaction of SOS-1 to Tie2 bound Grb2
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR
WIP binds WASP,N-WASP, activating them
Src phosphorylate WASP,N-WASP
PI3K phosphorylates PIP2 to PIP3
Recruitment of GADS:SLP-76 to p-5Y-LAT
Phosphorylation of SLP-76 by p-SYK
Recruitment of GRB2:SOS to p-5Y-LAT
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
PI3K inhibitors block PI3K catalytic activity
Activation of RAC1 by VAV2/3
SOS mediated nucleotide exchange of RAS (SHC)
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Phosphorylation of TEC kinases by p-SYK
Recruitment of GRB2:SOS to p-10Y-NTAL
Activation of RAC1 by VAV
Phosphorylation and activation of VAV
PI3K associates with phosphorylated GAB2
Interaction of GRB2:SOS complex with p-SHC1
Hydrolysis of PIP2 by PLCG
Phosphorylation of SLP-76 by p-SYK
Autophosphorylation of PAK
Autophosphorylation of BTK/ITK
Phosphorylation of PIP2 to PIP3 by PI3K
Recruitment of PAK to the membrane by binding active RAC1
Recruitment of VAV to p-SLP-76
Recruitment of GRB2 to p-PTK2
Interaction of SOS with GRB2 bound to FADK1
Activation of Rac1 by pVav1
Activation of Cdc42 by pVav1
Translocation of Vav1 to CD28
p-4Y-SIRPA:CD47 binds GRB2-1
Recruitment of Grb2 to pFAK:NCAM1
SOS binds Grb2 bound to pFAK:NCAM1
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
Phosphorylated SHC1 recruits GRB2:GAB2
Phosphorylated SHC recruits GRB2:SOS1
Gab2 binds the p85 subunit of Class 1A PI3 kinases
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant
Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
RAS GEFs promote RAS nucleotide exchange
GRB2-1:SOS1 binds p-Y-SHC
GRB2-1:SOS1 binds p-3Y-SHC1
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
GRB2-1:SOS1 binds p-IRS1,p-IRS2
GRB2-1:SOS1 binds p-Y427-SHC1
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
Activated MET recruits GRB2-1:SOS1
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
SHC1-2 bound to MET recruits GRB2:SOS1
Activated MET binds GAB1 and GRB2
Phosphorylated GAB1 recruits PI3K to MET
MET bound PI3K generates PIP3
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated
p-5Y-RET complexes bind GRB2
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
Epsin family proteins bind ubiquitinated cargo
EGFR phosphorylates EPS15
EGFR binds EPS15, EPN1, EPS15L1
PTPN3 dephosphorylates EPS15
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
CBL monoubiquitinates activated MET
CBL recruits CIN85:endophilin to ubiquitinated MET
EPS15 and HGS bind ubiquitinated MET
GAB1 recruits CRK,CRKL to MET
CRK,CRKL recruits RAC1 GEF to activated MET
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane
GGA3 associates with activated MET receptor
CBL binds InlB-activated MET
CBL monoubiquitinates InlB-bound MET
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
RHOU binds effectors at the plasma membrane
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
NTRK2-phosphorylated FRS2 binds GRB2
SHC1 mediates cytokine-induced phosphorylation of GAB2
The SHC1:SHIP1 complex is stabilized by GRB2
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
p-CD19:VAV binds PI3K and GRB2
Active FLT3:GRB2 binds SOS1
SOS1-mediated nucleotide exchange of RAS downstream of FLT3
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3
Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
KIT mutants bind GRB2-SOS
p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers
SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
GRB2:SOS1 complex binds to mutant PDGFR receptor
SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
FLT3 mutant dimers bind GRB2
FLT3 mutant dimers:GRB2 bind SOS1
FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
FLT3 mutants:GRB2 bind GAB2
FLT3 mutants phosphorylate GAB2
FLT3 ITD mutants phosphorylate STAT5
FLT3 ITD mutants bind STAT5 through GAB2:PTPN11
FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11
PTPN11:p-STAT5 dissociates from mutant FLT3
p-STAT5 dissociates from mutant FLT3
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
FLT3 mutants recruit PIK3CA through PIK3R1
FLT3 fusions:GRB2 bind SOS1
FLT3 fusions recruit PIK3CA through PIK3R1
FLT3 fusions phosphorylate GAB2
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
ALK mutants:p-3Y SHC binds GRB2
p-6Y-SYK phosphorylates BLNK (SLP65)
IRS1 recruits GRB2 to active LTK
Active LTK binds GRB2:TNK2
Active LTK recruits GRB2:SOS1
Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut
Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut
Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer
Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex
GRB2 deep research report (falcon / Edison Scientific)