Gene Ontology annotation through association of InterPro records with GO terms
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Source of IEA annotations for hydrolase activity, carbohydrate binding, cellulose binding, and carbohydrate metabolic process
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Identification of the cellulose-binding domain of the cellulosome subunit S1 from Clostridium thermocellum YS
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Original characterization of CipB (S1/SL) including identification of CBM domain
"The cellulose-binding domain in this polypeptide consisted of a C-terminal proximal 167 residue sequence which showed complete identity with residues 337-503 of mature SL from C. thermocellum strain ATCC 27405"
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Establishes CipB as a cellulosome subunit
"The 3' region of a gene designated cipB, which shows strong homology with cipA that encodes the cellulosome SL subunit of Clostridium thermocellum ATCC 27405, was isolated from a gene library of C. thermocellum strain YS"
Crystal structure of ScaC2 cohesin bound to CipB X-Doc complex
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1.98 A resolution structure showing type II cohesin-dockerin interaction
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Demonstrates Ca2+-dependent binding
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Identifies key specificity residues
UniProt entry for CipB/CIPB_ACETH
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CipB is a secreted scaffolding protein
"SUBCELLULAR LOCATION: Secreted. Note=Remains at cell surface"
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Contains cohesin domains, CBM3 domain, and dockerin domain
"DOMAIN: The cohesin domains bind to the dockerin domain born by the catalytic components of the cellulosome"
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Cohesin domains bind dockerin domains of catalytic enzymes
"The cohesin domains bind to the dockerin domain born by the catalytic components of the cellulosome"
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Functions in cellulosome organization
"FUNCTION: Acts as a scaffolding protein in the cellulosome. It promotes binding of cellulose to the catalytic domains of the cellulolytic enzymes"