The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.
Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages.
A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis.
The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.
reaper is required for neuroblast apoptosis during Drosophila development.
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila.
Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster.
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.
Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions.
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.
Drosophila IAP antagonists form multimeric complexes to promote cell death.
Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia.
Coordinated expression of cell death genes regulates neuroblast apoptosis.
Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.
Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.
Genetic control of programmed cell death in Drosophila.
Cell killing by the Drosophila gene reaper.
Activation of the reaper gene during ectopic cell killing in Drosophila.
Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).
Ras promotes cell survival in Drosophila by downregulating hid expression.
Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.
-
Reaper, Grim and Hid drive dredd RNA accumulation and Dredd precursor processing, and dredd heterozygosity suppresses reaper- and grim-induced cell killing.
"Heterozygosity at the dredd locus suppressed apoptosis in transgenic models of reaper- and grim-induced cell killing"
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection.
FlyBase gene description for rpr (DROME)