SREBP (HLH106, dSREBP; CG8522; UniProt Q9VW37) notes
- Membrane fraction precursor, nuclear processed form PMID:8577739.
- DNA binding and transactivation PMID:9632664;
[PMID:9632664 "The amino-terminal \"mature\" protein activates transcription from mammalian SREs in both mammalian and Drosophila tissue culture cells."]
- PE (not sterol) regulates processing in flies PMID:11988566.
- Mutants are fatty acid auxotrophs PMID:16753579
- Falcon deep research [file:DROME/SREBP/SREBP-deep-research-falcon.md "Loss of dSREBP reduces expression of acetyl-CoA synthase (ACS), acetyl-CoA carboxylase (ACC), and fatty-acid synthase (FAS)"].
- All annotations accepted except heterologous perinuclear membrane and miR-210 lipid droplet formation (kept non-core).