Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases.
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Eukaryotic GNATs act on many acceptor classes, and a large fraction of sequence clusters have no characterised member, so substrate class cannot be read from GNAT-domain membership alone.
"We identified 48 clusters with known acetyltransferases and 184 completely uncharacterized clusters."
NCU12035 bioinformatics checks (GNAT motif A, domain span, orthology)
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The GNAT domain covers residues 3-184 of 232 and keeps motif A (RRMGVG, 107-112). No PANTHER family is assigned, and the OrthoDB group contains only Neurospora genes.
"No characterised ortholog exists, and the absence of a PANTHER placement leaves no phylogenetic basis for transferring a substrate-specific function from another GNAT."
NCU12035 deep research (falcon)