Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10403843

DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation.

FAC1 DNA-binding affinity is regulated by phosphorylation in the reported nuclear-extract assays.

PMID:10575013

Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator.

Recombinant FAC1 recognizes a selected DNA sequence, and FAC1 represses a reporter containing that sequence in NIH3T3 cells.

PMID:10727212

Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.

FAC1 associates with MAZ and reduces MAZ-dependent reporter activation in an interaction-domain-dependent manner.

PMID:14609955

Isolation of human NURF: a regulator of Engrailed gene expression.

Human NURF contains BPTF and an ISWI ATPase, remodels chromatin as a complex, and regulates Engrailed expression.

PMID:15379550

Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

FAC1 associates with human KEAP1 and undergoes context-dependent cytoplasmic/perinuclear redistribution.

PMID:15640247

CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.

CECR2 and SNF2L form CERF, a chromatin-remodeling complex studied in neurulation; the comparative BPTF interaction assay remains uninspected.

PMID:18570454

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

Human neural-stem-cell exosome proteomics provides the dataset context for the BPTF localization assertion; the target identification record remains uninspected.

PMID:20850016

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

Quantitative histone-reader proteomics examines chromatin-associated protein assemblies; the original BPTF-specific complex table remains uninspected.

PMID:21596426

Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions.

The BPTF PHD–bromodomain module recognizes combined histone marks in a substrate-dependent manner; mutations affecting these interactions reduce full-length BPTF recruitment at HOXA9.

PMID:22729083

Diverse epigenetic strategies interact to control epidermal differentiation.

BPTF and SMARCA5 contribute to regulation of human epidermal differentiation in genetic and tissue-reconstitution experiments.

PMID:25593309

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

BPTF is among the bromodomain proteins reported to accumulate at DNA-damage sites; the ZMYND8-specific repair mechanism is not assigned to BPTF.

PMID:27141965

Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.

BPTF/NURF occupancy at erythroid promoters is linked to chromatin accessibility and transcriptional regulation.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

OpenCell maps endogenous protein localization and associations in human cells; the BPTF-specific interaction entries remain uninspected.

PMID:7621746

FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain.

FAC1 abundance and nuclear/cytoplasmic localization change during human cortical development.

PMID:9225734

FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord.

FAC1 expression and nuclear/cell-body localization vary in developing, adult and ALS spinal-cord motor neurons.

file:human/BPTF/BPTF-uniprot.txt

UniProtKB Q12830 (BPTF_HUMAN), nucleosome-remodeling factor subunit BPTF

BPTF is a regulatory NURF subunit with histone-recognition domains and three named products whose internal sequence changes are recorded independently.

PMID:15310751

A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.

The inactive SMARCA1/SNF2L+13 splice variant retains incorporation into protein complexes, separating motor competence from complex assembly.

"SNF2L+13 retains the ability to incorporate into multiprotein complexes; however, it is devoid of enzymatic activity."

PMID:16728976

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

BPTF PHD recognition of H3K4me3 couples NURF chromatin association and recruitment to histone methylation; the developmental loss-of-function experiment is in Xenopus.

PMID:16728978

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

Structures and affinity measurements establish direct H3K4me3 recognition by the human BPTF PHD finger, with a preference over H3K4me2 and discrimination against lower methylation states.

PMID:18042461

Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.

Engineered Y17E changes BPTF PHD methylation-state preference toward H3K4me2; this differs from wild-type H3K4me3 preference.

"following Y17E substitution, which shows a reversal from tri- to dimethylation state preference"

PMID:28801535

Expansion of the ISWI chromatin remodeler family with new active complexes.

Endogenous BPTF coassociation with SMARCA1 and SMARCA5 is supported, while BPTF was excluded from the recombinant purification panel.

"with the exception of the 340‐kDa BPTF"