Gene Ontology annotation through association of InterPro records with GO terms

UniProtKB:A0A0H2M0U4

UniProtKB record A0A0H2M0U4 (A0A0H2M0U4_VARPD) - Cobalt-zinc-cadmium resistance protein CzcC from Variovorax paradoxus TBEA6

VPARA_44910 (czcC, A0A0H2M0U4) is a 445-aa outer-membrane efflux protein containing an N-terminal signal peptide (residues 1-20), a mature chain (residues 21-445) with two Pfam PF02321 OEP repeats, and membership in InterPro IPR003423 and PANTHER PTHR30203 (OUTER MEMBRANE CATION EFFLUX PROTEIN).

"DR PANTHER; PTHR30203; OUTER MEMBRANE CATION EFFLUX PROTEIN; 1."

PMID:10559151

CzcD is a heavy metal ion transporter involved in regulation of heavy metal resistance in Ralstonia sp. strain CH34.

In Ralstonia (Cupriavidus) metallidurans CH34, CzcC assembles with CzcB and CzcA into the tripartite CzcCB2A cation-proton antiporter that exports cobalt, zinc, and cadmium ions across the cell envelope.

"The Czc system of Ralstonia sp. strain CH34 mediates resistance to cobalt, zinc, and cadmium through ion efflux catalyzed by the CzcCB(2)A cation-proton antiporter."

PMID:12829273

Efflux-mediated heavy metal resistance in prokaryotes.

Tripartite CBA efflux complexes driven by RND antiporters export heavy metal cations across both the inner and outer membranes of Gram-negative bacteria.

"The mechanisms of action, physiological functions, and distribution of metal-exporting proteins are outlined, namely: CBA efflux pumps driven by proteins of the resistance-nodulation-cell division superfamily, P-type ATPases, cation diffusion facilitator and chromate proteins, NreB- and CnrT-like resistance factors."