Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Identification of two gene clusters and a transcriptional regulator required for Pseudomonas aeruginosa glycine betaine catabolism.
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Mutations in dgcAB (PA5398-PA5399) block the conversion of dimethylglycine to sarcosine; the genes were identified by loss of growth on glycine betaine and dimethylglycine and by 13C NMR with labelled choline, and they are homologous to genes encoding demethylases.
"with mutations in the dgcAB (PA5398-PA5399) genes, which exhibit homology to"
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dgcAB is induced by glycine betaine and dimethylglycine through the AraC-family regulator GbdR (PA5380).
"growth on GB and DMG and for the induction of gbcA, gbcB, and dgcAB in response"
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Glycine betaine is an intermediate in choline and carnitine catabolism and can serve as sole carbon or nitrogen source for P. aeruginosa.
"intermediate in the catabolism of choline and carnitine, can serve as a sole"
UniProt entry Q9HTG5 (dgcB, PA5399)