COQ1 (YBR003W, P18900) notes

Hexaprenyl diphosphate synthase.

• coq1 strain lacking hexaprenyl pyrophosphate synthetase activity complemented by COQ1 PMID:2198286.
• coq1 mutants expressing heterologous synthases make UQ5-UQ10 PMID:9708911.
• Peripheral, matrix side of inner membrane PMID:15548532.
• GOA IMP GO:0000010 "heptaprenyl diphosphate synthase activity" is wrong chain length (C35 vs C30); its synonym "trans-hexaprenyltranstransferase activity" likely caused the mis-mapping. MODIFY -> GO:0036423 hexaprenyl-diphosphate synthase ((2E,6E)-FPP specific) activity, matching modules/ubiquinone_biosynthesis.yaml. Primer specificity (FPP vs GGPP) untested for yeast Coq1p; YeastPathways draws geranylfarnesyl-PP + IPP.
• UniProt has no catalytic-activity line for COQ1.
• IBA part_of polyprenyl diphosphate synthase complex: seeded from heteromeric PDSS1/2, Dps1/Dlp1; no second subunit known in S. cerevisiae -> non-core.
• protein binding IPI (Gavin 2006) -> over-annotated.