Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.
Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.
Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
cAMP-independent activation of the adenovirus type 12 E2 promoter correlates with the recruitment of CREB-1/ATF-1, E1A(12S), and CBP to the E2-CRE.
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.
CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus.
The sonic hedgehog-patched-gli pathway in human development and disease.
Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.
A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.
Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP.
Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.
Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.
The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.
Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription.
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro.
The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes.
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
Interferon regulatory factor-2 regulates cell growth through its acetylation.
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies.
HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.
NF-kappaB RelA phosphorylation regulates RelA acetylation.
Crystal structure of IRF-3 in complex with CBP.
A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator.
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.
Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx.
Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.
Acetylation-dependent signal transduction for type I interferon receptor.
Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia.
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway.
Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1.
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.
Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells.
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18.
The corepressor activity of Alien is controlled by CREB-binding protein/p300.
Structural insights into the functions of TBK1 in innate antimicrobial immunity.
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.
Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP.
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
Roles of tau protein in health and disease.
Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.
SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.
SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.
Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.
In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5.
Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.
Human transcription factor protein interaction networks.
Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
Quantitative fragmentomics allow affinity mapping of interactomes.
Metabolic regulation of homologous recombination repair by MRE11 lactylation.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
Nuclear protein CBP is a coactivator for the transcription factor CREB.
Human p300 protein is a coactivator for the transcription factor MyoD.
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.
Synergistic activation of transcription by CBP and p53.
Binding and modulation of p53 by p300/CBP coactivators.
RNA helicase A mediates association of CBP with RNA polymerase II.
E1A directly binds and regulates the P/CAF acetyltransferase.
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Formation of VAF (virus-activated factor) complex
Formation of HIF:CBP:p300 complex at promoters
NICD1 in complex with RBPJ (CSL) recruits MAML
Formation of CSL-NICD coactivator complex
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
CDK8 phosphorylates NICD1 PEST domain mutants
Beta-catenin enhances association of IRF3 with CBP/p300
Beta-catenin recruits CBP/p300
HSF1 acetylation at Lys80
HSF1-dependent transactivation
Fatty acid ligands activate PPARA
NOTCH1 Coactivator Complex binds MYC promoter
NOTCH1 Coactivator Complex binds HES5 promoter
NOTCH1 PEST domain mutants bind HES1 promoter
NOTCH1 PEST domain mutants bind MYC promoter
NOTCH1 PEST domain mutants bind HES5 promoter
NOTCH1 PEST domain mutants bind promoters of HEY genes
C-type lectin receptors (CLRs)
p300 acetylates RELA subunit
CBP and p300 binds NF-kB complex
TP53 and CREBBP bind BNIP3L gene
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
RUNX3 binds the NOTCH1 coactivator complex
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter
NOTCH1 coactivator complex binds NOTCH3 gene
NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
GREB1 binds ESR1:ESTG and co-activators
p-IRF7 dimer interacts with coactivator CBP/p300
CREBBP acetylates SARS-CoV-2 N at K375
AcK-NFE2L2 binds the TXNRD1 promoter
CREBBP, EP300 acetylates NFE2L2
NFE2L2 binds CREBBP,EP300
AcK-NFE2L2 and MAFK bind the GSTA1 gene
AcK-NFE2L2 binds the GCLC gene
AcK-NFE2L2 binds the GCLM gene
AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
AcK-NFE2L2 and ATF4 bind the SLC7A11 gene
NFE2L2 binds the PGD gene
p14ARF binds NFE2L2:CREBBP, EP300
AcK-NFE2L2 binds the ABCF2 gene
AcK-NFE2L2 binds the ABCG2 gene
AcK-NFE2L2 binds the SOD3 gene
AcK-NFE2L2 binds the KEAP1 gene
AcK-NFE2L2 binds the AREG gene
AcK-NFE2L2 binds the TXN gene
AcK-NFE2L2 binds the BCL2 gene
AcK-NFE2L2 binds the NOTCH1 gene
AcK-NFE2L2 binds the ABCC3 gene
AcK-NFE2L2 binds the CCL2 gene
AcK-NFE2L2 binds the ATF4 gene
AcK-NFE2L2 binds the ABCC1 gene
AcK-NFE2L2 binds the EGF gene
AcK-NFE2L2 binds the BCL2L1 gene
CREBBP acetylates HINT1 dimer
Coactivators are recruited to liganded PPARG:RXRA heterodimer
NFE2L2 binding to CD274 gene
MITF-M binds CREBBP,EP300
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells.
Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation.
Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription.
Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes.
Author Correction: Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.
CREBBP source identities, experimental scope and propagation evidence