Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.
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The human NatB complex consists of the catalytic subunit hNAT3 (NAA20) and the auxiliary subunit hMDM20 (NAA25); they form a stable complex with sequence-specific N-terminal acetyltransferase activity on Met-Asp- N-termini.
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hNAT3 and hMDM20 co-sediment with ribosomal pellets, supporting co-translational action of NatB on nascent polypeptides.
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Knockdown of hMDM20 (NAA25) disrupts normal cell-cycle progression and inhibits growth of HeLa cells.
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.