Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.
A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway.
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.
Distinct factors control histone variant H3.3 localization at specific genomic regions.
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.
H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes.
Proteomic characterization of the human sperm nucleus.
Structures of human nucleosomes containing major histone H3 variants.
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
A reference map of the human binary protein interactome.
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
De novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities.
PRC2 recruits DNA methyltransferases
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin
PRC2 trimethylates histone H3 at lysine-27
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
KDM6B demethylates H3K27me3 on p16INK4A promoter
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
p-MAPKAPK3 phosphorylates BMI1
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
EHMT1:EHMT2 methylates IL8 promoter
EHMT1:EHMT2 methylates IL6 promoter
MBD2 binds methylcytosine in chromatin
eNoSC deacetylates histone H3
eNoSC dimethylates histone H3 at lysine-9
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
AGO1,2:small RNA complexes interact with chromatin
PKN1:AR complex binds promoters of KLK2 and KLK3 genes
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
Demethylase KDM4C binds KLK2 and KLK3 promoters
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
Demethylase KDM1A binds KLK2 and KLK3 promoters
KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
RUNX1 and GATA1 bind the promoter of the ITGA2B gene
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
RUNX1 and GATA1 bind the promoter of the GP1BA gene
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
RUNX1 and GATA1 bind the promoter of the THBS1 gene
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
RUNX1 and GATA1 bind the promoter of the MIR27A gene
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
FOXA1 and GATA3 bind to CCND1 promoter
Binding of AP1 transcriptional activator complexes to CCND1 promoter
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers
EP300 is recruited to MYC and BCL2 genes
Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes
KDM1A is recruited to MYC and BCL2 genes
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
NR5A2, ZNF217 and NCOA3 bind GREB1 promoter
Histone H3.3 deposition at telomere
The GSDME gene promoter is hypermethylated
PRC2 (EZH2) core complex binds CDH1 gene promoter
PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
Serum amyloid P binds DNA and chromatin
SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes
KRAB-ZFP binds retroelement DNA in chromatin
ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin
Unliganded PPARG:RXRA heterodimer recruits corepressors to target gene loci
Corepressors are released from liganded PPARG:RXRA heterodimer
Coactivators are recruited to liganded PPARG:RXRA heterodimer
CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome
factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)
CD274 gene binding to Nucleosome
PRC2(EZH2) core binding to CD274 gene promoter
Trimethylation of CD274 gene chromatin by MLL1/3 complex
Trimethylation of CD274 gene promoter by EZH2
BRD4 binding to CD274 gene chromatin
MLL1,MLL3 complex binding to CD274 gene chromatin
HP1 alpha binds Histone H3K9(me)3
ZNF827 and NR2C2,NR2F2 recruit NuRD to telomeric chromatin
NuRD deacetylates telomeric nucleosomes
CHD1 and CHD2 bind H3K4me3 nucleosomes
CHD1:H3K4me3 interacts with post-initiation transcription complexes
CHD6-9-dependent ATP hydrolysis
NuRD deacetylates nucleosomes
NuRD binds TCF19 at FBP1 gene
NuRD binds TCF19 at G6PC gene
NuRD binds TCF19 at PCK1 gene
JMJD1C demethylates H3K9 mono- and di-methylation
H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phase.
The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3.
Histone H3.3 maintains genome integrity during mammalian development.
Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts.
UniProtKB P84243: Histone H3.3
H3-3A primary-source checks and provenance