Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:16982419

The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.

DOCK7 promotes axon formation through Rac-dependent microtubule regulation.

PMID:18850735

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

Endogenous DOCK7 associates with affinity-purified human COP9 signalosome.

PMID:21423176

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.

Focal-adhesion proteomics provides contextual localization evidence.

PMID:22158624

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

DOCK7 depletion reduces human pulmonary arterial smooth-muscle cell migration.

PMID:23553822

Altered thermogenesis and impaired bone remodeling in Misty mice.

Misty Dock7-mutant mice have altered sympathetic/thermogenic physiology and compensatory white-fat browning.

PMID:24255178

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Curated AP-MS records associate DOCK7 with LRCH proteins.

PMID:27812135

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

DOCK7–NOD2 interaction is positive in yeast two-hybrid and BRET but negative in the reported co-immunoprecipitation.

PMID:29187380

Nbeal2 interacts with Dock7, Sec16a, and Vac14.

DOCK7 associates with NBEAL2 and SEC16A in human cellular complexes.

PMID:29467281

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

LRCH proteins associate with DOCK7, and LRCH3 plus an engineered DOCK7 fragment reorganizes septin rings.

PMID:32203420

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

DOCK7 associates with LRCH proteins and can be recruited to peripheral cytoskeletal sites.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

BioPlex supplies human DOCK7–LRCH complex-association records.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Endogenous-tagged DOCK7 recovers LRCH1 and LRCH3 in OpenCell.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

Human U2OS AP-MS recovers DOCK7 as a prey of LRCH1 and LRCH3.

PMID:22842144

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.

DOCK7 regulates cortical nuclear migration through TACC3 independently of its exchange domain.

PMID:23718289

Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.

Human DOCK7 DHR2 fragments catalyze exchange on prenylated RAC1 and CDC42 associated with liposomes.

PMID:22634526

The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42.

Fly Zir genetically interacts with Rac2 and Cdc42 in cellular immune responses.

UniProtKB:Q96N67

UniProtKB Q96N67: DOCK7_HUMAN

Seven official products differ by internal alternative segments or a C-terminal truncation.

Reactome:R-HSA-8875591

DOCK7 activates RAC1

DOCK7 is represented as a cytosolic member of the active GEF candidate set for RAC1 activation.

file:human/DOCK7/DOCK7-bioinformatics/constructs/RESULTS.md

DOCK7 experimental construct sequence analysis

Deposited experimental sequences differ from current full-length natural-product labels; exact sequence blocks are reproduced from primary inputs.

file:human/DOCK7/DOCK7-bioinformatics/interactions/RESULTS.md

DOCK7 public interaction record extraction

The saved primary AP-MS and OpenCell datasets independently resolve the LRCH1/LRCH3 source records with bait direction and full accession groups.