Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.
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pink-1 mutants have reduced mitochondrial cristae length and increased paraquat sensitivity
"a mutation in the Caenorhabditits elegans homologue of the PTEN-induced kinase pink-1 gene resulted in reduced mitochondrial cristae length and increased paraquat sensitivity of the nematode"
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pink-1 mutants display axon guidance defects in CAN neurons
"the mutants also displayed defects in axonal outgrowth of a pair of canal-associated neurons"
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lrk-1 loss suppresses all pink-1 phenotypes
"in the absence of lrk-1, the C. elegans homologue of human LRRK2, all phenotypic aspects of pink-1 loss-of-function mutants were suppressed"
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pink-1 loss reduces lrk-1 ER stress sensitivity (tunicamycin)
"the hypersensitivity of lrk-1 mutant animals to the endoplasmic reticulum stressor tunicamycin was reduced in a pink-1 mutant background"
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
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PINK-1/PDR-1 pathway is essential for mitophagy in C. elegans
"DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans"
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Mitophagy coordinates with mitochondrial biogenesis during aging
"mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity"
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Impairment of mitophagy compromises stress resistance
"Impairment of mitophagy compromises stress resistance and triggers mitochondrial retrograde signalling"
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.
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Metabolite-induced autophagy is PINK-1 dependent
"the induced autophagy observed in metabolite-treated animals is PINK-1 dependent"
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PINK-1 is required for stress-induced autophagic response
"animals with reduced pink-1 no longer have increased mCherry::LGG-1 accumulation in the presence of the metabolite"
Deep research on C. elegans pink-1
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PINK-1 is a mitochondrial stress-activated serine/threonine kinase
"PINK-1 is a mitochondrial stress-activated serine/threonine kinase whose substrates include ubiquitin (Ser65) and Parkin/PRKN (Ser65)"
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PINK-1 localizes to mitochondria with a cytoplasmic pool
"A rescuing Ppink-1::pink-1::gfp transgene shows broad expression in neurons and other tissues with partial mitochondrial co-localization"
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pink-1 loss reduces mitochondrial cristae length
"pink-1 loss reduces mitochondrial cristae length (approximately 12% reduction in body-wall muscle; >30% in neurons)"