Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

PDK1 regulates growth through Akt and S6K in Drosophila.

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development.

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

A genome-wide resource for the analysis of protein localisation in Drosophila.

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation.

Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Activation of DAkt1 by DPDK1

DPDK1 phosphorylates and activates DS6K