Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic Gene Ontology annotation based on Rhea mapping
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProt entry Q88FC9 (GPDA_PSEPK), Glycerol-3-phosphate dehydrogenase [NAD(P)+], annotated by HAMAP-Rule MF_00394
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GpsA reduces the glycolytic intermediate dihydroxyacetone phosphate to sn-glycerol 3-phosphate, the key precursor for phospholipid synthesis (EC 1.1.1.94), using NAD(H) or NADP(H), and is a cytoplasmic member of the NAD-dependent glycerol-3-phosphate dehydrogenase family.
"Catalyzes the reduction of the glycolytic intermediate"
Curator research notes for gpsA (Q88FC9), P. putida KT2440
PANTHER family PTHR11728 (NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) and subfamily PTHR11728:SF1 (GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC)
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GpsA is classified in PANTHER family PTHR11728 (GLYCEROL-3-PHOSPHATE DEHYDROGENASE) and subfamily PTHR11728:SF1 (GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC).
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The ", CHLOROPLASTIC" subfamily tag is a eukaryote-biased naming artifact reflecting the plant/algal reference members; the bacterial enzyme is the biosynthetic NAD(P)+ glycerol-3-phosphate dehydrogenase that produces G3P, so the classification supports the biosynthetic (G3P-producing) GpsA assignment.
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.