Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Paralogous chemoreceptors mediate chemotaxis towards protein amino acids and the non-protein amino acid gamma-aminobutyrate (GABA).
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The PctC ligand binding region binds two L-amino acids and GABA, and a pctC mutant loses chemoattraction to GABA.
"In addition, PctC-LBR recognized GABA but not any other structurally related compound."
Genetic identification of chemotactic transducers for amino acids in Pseudomonas aeruginosa.
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Cloned pctC restores chemotaxis to L-His and L-Pro in a strain lacking the whole pct region.
"The pctB and pctC genes complemented the defect in chemotaxis to only seven (Ala, Arg, Glu, Lys, Met, Tyr, Gln) and two (His, Pro) L-amino acids, respectively."
Identification of chemosensory proteins for trichloroethylene in Pseudomonas aeruginosa.
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pctC mutants show decreased repellent responses to TCE, chloroform and methylthiocyanate.
"This result demonstrates that PctA, PctB and PctC are also involved in repellent responses to chloroform and methylthiocyanate."
High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa.
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PctC contributes to histamine chemotaxis together with TlpQ and PctA.
"This chemotactic response is mediated by the concerted action of the TlpQ, PctA, and PctC chemoreceptors"
How Bacterial Chemoreceptors Evolve Novel Ligand Specificities.
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PctB and PctC are paralogues of the broad-range amino acid receptor PctA with narrow ligand preferences.
"PctA has a broad ligand range and responds to most of the proteinogenic amino acids, whereas PctB and PctC have a much narrower range"