Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs using sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs by Ensembl Compara

Electronic GO annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity.

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.

DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3.

CHIP interacts with heat shock factor 1 during heat stress.

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

Akt and CHIP coregulate tau degradation through coordinated interactions.

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.

C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.

Global landscape of HIV-human protein complexes.

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.

Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.

The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

A proteome-scale map of the human interactome network.

UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

Roles of tau protein in health and disease.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

A reference map of the human binary protein interactome.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.

Interactome dynamics of RAF1-BRAF kinase monomers and dimers.

Multimodal cell maps as a foundation for structural and functional genomics.

Reactome pathway R-HSA-1227986

Reactome pathway R-HSA-1918092

Reactome pathway R-HSA-2173788

Reactome pathway R-HSA-2187368

Reactome pathway R-HSA-2187375

Reactome pathway R-HSA-6807134

Reactome pathway R-HSA-9009308

Reactome pathway R-HSA-9009309

Reactome pathway R-HSA-9688831

Reactome pathway R-HSA-9688838

Reactome pathway R-HSA-9796368

Reactome pathway R-HSA-9796387