Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors
MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
Proteomics characterization of extracellular space components in the human aorta
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
Extracellular matrix remodelling in response to venous hypertension proteomics of human varicose veins
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics
Agrin binds to the nerve-muscle basal lamina via laminin
Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane
Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue
Primary structure and high expression of human agrin in basement membranes of adult lung and kidney
Lrp4 is a receptor for Agrin and forms a complex with MuSK
Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
Identification of an agrin mutation that causes congenital myasthenia and affects synapse function
Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn
The Role of Agrin in Synaptic Development, Plasticity and Signaling in the Central Nervous System
Agrin in the developing CNS - new roles for a synapse organizer
The extracellular matrix protein agrin promotes heart regeneration in mice
Anti-agrin autoantibodies in myasthenia gravis
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions
Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation
Physiological regulation of the immunological synapse by agrin
Deep research analysis of AGRN gene function and mechanisms
Falcon deep research analysis of AGRN gene function
Cyberian deep research analysis of AGRN gene function
UniProt record for human agrin protein
Heparanase cleaves heparan sulfate from proteoglycan in lysosome
AGRN binds Beta amyloid fibril via GAG chains
DGC complex binds AGRN and HSPG2
Agrin binds Integrin alphaVbeta1
Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans
XYLTs transfer Xyl to core protein
B3GAT dimers transfer GlcA to tetrasaccharide linker
B3GALT6 transfers Gal to the tetrasaccharide linker
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker
EXT1:EXT2 transfers GlcNAc to the heparan chain
EXT1:EXT2 transfers GlcA to heparan
NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
NDST1-4 N-deacetylates GlcNAc residues in heparan
HS-GAGs translocate to the lysosome for degradation
Some HSPGs are secreted to the plasma membrane
HS3ST1 sulfates GlcN at C3 in heparan sulfate
EXT1:EXT2 transfers GlcA to heparan
HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate
HS3ST2-6 sulfate GlcN at C3 in heparan sulfate
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
CR:atREs binds apoE and HSPG
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs
Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker
Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker
Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan
Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan
Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
PXYLP1 dephosphorylates Xyl moiety
FAM20B phosphorylates Xyl moiety
EXTL3 dimer transfers GlcNAc to the GAG linker
Thermodynamic and structural studies of carbohydrate binding by the agrin-G3 domain.
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo.
Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clusters.
Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex.
Agrin is a heparan sulfate proteoglycan.
The agrin receptor. Localization in the postsynaptic membrane, interaction with agrin, and relationship to the acetylcholine receptor.
The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans.
Identification of extracellular matrix ligands for the heparan sulfate proteoglycan agrin.
Calcium plays a critical role in determining the acetylcholine receptor-clustering activities of alternatively spliced isoforms of Agrin.
Fibronectin fibrillogenesis, a cell-mediated matrix assembly process.
Alpha3Na+/K+-ATPase is a neuronal receptor for agrin.
Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier.
Structural basis of agrin-LRP4-MuSK signaling.
The Basement Membrane Proteoglycans Perlecan and Agrin: Something Old, Something New.
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.
Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons.
Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.
AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target.
Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation.
Alternative RNA splicing that determines agrin activity regulates binding to heparin and alpha-dystroglycan.
Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier.
Electron microscopic structure of agrin and mapping of its binding site in laminin-1.
alpha-Dystroglycan is a laminin receptor involved in extracellular matrix assembly on myotubes and muscle cell viability.
Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors.
Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain.
Agrin isoforms with distinct amino termini: differential expression, localization, and function.
Neural agrin controls acetylcholine receptor stability in skeletal muscle fibers.
Acetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins.
Agrin and laminin induce acetylcholine receptor clustering by convergent, Rho GTPase-dependent signaling pathways.
The process-inducing activity of transmembrane agrin requires follistatin-like domains.
Asparagine of z8 insert is critical for the affinity, conformation, and acetylcholine receptor-clustering activity of neural agrin.
Glomerular basement membrane composition and the filtration barrier.
Nanoscale protein architecture of the kidney glomerular basement membrane.
Achieving Acetylcholine Receptor Clustering in Tissue-Engineered Skeletal Muscle Constructs In vitro through a Materials-Directed Agrin Delivery Approach.
Congenital myasthenic syndrome-associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner.
Novel NtA and LG1 Mutations in Agrin in a Single Patient Causes Congenital Myasthenic Syndrome.
The Current State of Extracellular Matrix Therapy for Ischemic Heart Disease.
Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review).
Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics.
Agrin/Dok-7-induced JPH2 phosphorylation in muscle cells is involved in AChR clustering.
Implication of geranylgeranyltransferase I in synapse formation.
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice.