Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
Caspase-10 is an initiator caspase in death receptor signaling.
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.
RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.
Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
Toward an understanding of the protein interaction network of the human liver.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10
TP53 stimulates CASP10 expression
Dimerzation of procaspase-8, procaspase-10
Recruitment of caspase-8 and -10 to FADD complex
Recruitment of IKK complex