Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Deep research on Stx2A function and mechanism
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rRNA N-glycosylase mechanism confirmed
"Stx2A1 is an rRNA N-glycosylase that removes a specific adenine from the SRL of 28S rRNA, blocking elongation factor-dependent GTPase function and halting translation"
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P-stalk recruitment for ribosome targeting
"Cryo-EM shows the native P-stalk pentamer engages Stx2a with nanomolar affinity; X-ray structures localize the P-stalk peptide binding pocket on Stx2A1"