MEU1 (YLR017W, Q07938) notes
- MTA phosphorylase, EC 2.4.2.28, PNP/MTAP family, homotrimer [UniProt:Q07938 "Reaction=S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-"].
- Identified as MTAP; meu1 cells have elevated ODC and polyamines PMID:14506228. KMTB represses ODC (feedback from salvage to polyamine synthesis).
- Verified by Pirkov 2008 PMID:18625006.
- Originally isolated as multicopy enhancer of UAS2-dependent ADH2 expression PMID:8807288; diffuse localization PMID:8807288.
- SGD IMP "L-glutamate biosynthetic process" from PMID:8807288: abstract does not mention glutamate; WebFetch of PMC1207385 returned no glutamate phenotype either (likely only partial text) -> UNDECIDED.
- mRNA binding: Meu1 associated with its own mRNA PMID:21124907 -> non-core.