Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Complex regulation of the human gene for the Z-DNA binding protein DLM-1.
Intracellular localization of human ZBP1: Differential regulation by the Z-DNA binding domain, Zalpha, in splice variants.
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins.
Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.
Host cell Z-RNAs activate ZBP1 during virus infections.
Host Z-RNAs: the endogenous trigger for ZBP1 activation during pathogen infection.
ZBP1's Inability to Convert Unmodified RNAs to the Z-form Underlies a Balanced Mechanism of RNA Recognition with ADAR1.
Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1.
Phosphorylation and release of IRF3
ZBP1(DAI) recruits RIP1 and RIP3
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1