Falcon deep research report for HSPA6
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human Neurons
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HSPA6 was among the most strongly induced HSP70 paralogs in neuronal heat-stress models, with approximately 13-14-fold induction under extreme heat vs approximately 2-3-fold under mild heat. Gene expression peaked at approximately 1 hour and protein at approximately 5-6 hours post-stress. Co-expressed with DNAJB1, BAG3, and HSPH1/HSP110 as a coordinated inducible chaperone module.
Is It Still Possible to Think about HSP70 as a Therapeutic Target in Onco-Hematological Diseases?
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Describes canonical HSP70 architecture including N-terminal ATPase domain, substrate-binding domain with lid, and C-terminal EEVD motif. J-domain proteins deliver clients and stimulate hydrolysis; NEFs (BAG-family, HSPBP1) promote ADP release. HSP110 proteins cooperate with HSP70 and HSP40 for disaggregation. HSP70 inhibitors have not reached the clinic despite extensive preclinical work.
Identification and characterization of proteins that are involved in RTP1S-dependent transport of olfactory receptors
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HSPA6 was biotinylated by RTP1S-AirID (proximity-labeling), indicating physical proximity. Co-expression of HSPA6 partially enhanced surface expression of olfactory receptor Olfr544 by approximately 50-80%. RTP1S N-terminus interacts with HSPA6 C-terminal domain; the olfactory receptor itself did not significantly interact with HSPA6, suggesting indirect trafficking role via RTP1S.
The Interplay between Heat Shock Proteins and Cancer Pathogenesis: A Novel Strategy for Cancer Therapeutics
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Updated 2024 review of HSP70 family in cancer biology. Summarizes co-chaperone regulation (DNAJ/HSP40, BAG proteins, HSP110, CHIP) and HSF1-driven transcriptional control. Supports consensus that inducible HSP70 family members like HSPA6 contribute to tumor phenotypes when dysregulated.
Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains
BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression
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BARX1 overexpression increases HSPA6 expression (RNA-seq, qPCR, Western blot). Dual-luciferase reporter supports direct regulation at HSPA6 promoter. Silencing HSPA6 attenuates BARX1-driven osteosarcoma proliferation and migration/invasion in vitro.