Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome.
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First reported patient with PIGW deficiency (GPIBD11): West syndrome with hypsarrhythmia, developmental delay, dysmorphic features and hyperphosphatasia, with decreased surface expression of GPI-anchored proteins on blood granulocytes; compound heterozygous PIGW variants.
"involved in the addition of the acyl-chain to inositol in an early step of GPI"
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
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Fourth step of GPI synthesis: an acyl group (typically palmitate) is transferred from acyl-CoA to glucosaminyl-PI; PIG-W catalyses this reaction.
"In the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI."
Synthesis of glycosylphosphatidylinositol (GPI)
UniProtKB Q7Z7B1 PIGW record
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PIGW is an ER multi-pass membrane acyltransferase that acylates the inositol of GlcN-PI at the fourth step of GPI-anchor biosynthesis; deficiency causes GPIBD11.
"participates in the fourth step of GPI-anchor biosynthesis"