Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
BRCA1 supports XIST RNA concentration on the inactive X chromosome.
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Nuclear targeting and cell cycle regulatory function of human BARD1.
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.
MERIT40 facilitates BRCA1 localization and DNA damage repair.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.
Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
BRCA1 tumor suppressor network: focusing on its tail.
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Isomerization of BRCA1-BARD1 promotes replication fork protection.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
BRCA1/BARD1 is a nucleosome reader and writer.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Identification of a RING protein that can interact in vivo with the BRCA1 gene product.
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.
BRCA1 forms a heterodimer with BARD1
Formation of BRCA1-A complex at DNA DSBs
CHEK2 is recruited to DNA DSBs
CHEK2 phosphorylates BRCA1
BRCA1 binds phosphorylated RBBP8
Binding of ATR:ATRIP to RPA at resected DNA DSBs
CHEK1 is recruited to resected DNA DSBs
Activation of CHEK1 at resected DNA DSBs
ATR activation at DNA DSBs
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
Long-range resection of DNA DSBs by EXO1 or DNA2
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
RAD52 promotes single strand annealing at resected DNA DSBs
ERCC1:XPF cleaves flaps generated by SSA
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
BRCA1-A complex deubiquitinates K63polyUb-histone H2A
Ligation of DNA and formation of Holliday structures following repair synthesis
Association of RPA complexes with ssDNA at resected DNA DSBs
Phosphorylation of BRCA1-A complex at multiple sites by ATM
RAD51 binds BRCA2 at resected DNA DSBs
Association of RAD51 with RAD52:DNA double-strand break ends
Association of RAD52 with the RPA complex at resected DNA DSBs
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
Initial resection of double-strand break ends
D-loop formation mediated by PALB2, BRCA2 and RAD51
Phosphorylation and activation of CHEK2 by ATM
Some pathogenic BRCA1 mutants do not bind BARD1
Defective BARD1 does not bind BRCA1
BAP1 disrupts the BRCA1:BARD1 heterodimer
BRCA1:BARD1 heterodimer autoubiquitinates
BAP1 binds BRCA1:BARD1 heterodimer
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
UBXN1 binds BRCA1:BARD1 heterodimer
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.